| 许晨1, 赵沛莹1, 刘凤娇1, 王曦1,2, 康珊珊1,2, 袁龙飞1,赵莉蔺1, 李薇1, 陈增龙1*.基于缬菌胺和代森锰锌残留特征及膳食暴露风险评估[J].植物保护,2024,50(2):119-128. |
| 基于缬菌胺和代森锰锌残留特征及膳食暴露风险评估 |
| Residual characteristics and dietary exposure risk assessment of valifenalate and mancozeb |
| 投稿时间：2023-01-19 修订日期：2023-02-28 |
| DOI：10.16688/j.zwbh.2023029 |
| 中文关键词: 缬菌胺 代森锰锌 环境行为 风险评估 储藏稳定性 |
| 英文关键词:valifenalate mancozeb environmental fate risk assessment storage stability |
| 基金项目:国家自然科学基金（31801771，32230066） |
| 作者 | 单位 | E-mail | | 许晨1, 赵沛莹1, 刘凤娇1, 王曦1,2, 康珊珊1,2, 袁龙飞1,赵莉蔺1, 李薇1, 陈增龙1* | 1. 中国科学院动物研究所农业虫害鼠害综合治理研究国家重点实验室, 农药残留分析研究中心, 北京100101
2. 河北大学生命科学学院, 保定071002 | chenzenglong@ioz.ac.cn |
|
| 摘要点击次数: 68 |
| 全文下载次数: 69 |
| 中文摘要: |
| 本文建立了缬菌胺、代森锰锌及其代谢物乙撑硫脲(ethylenethiourea, ETU)在葡萄和黄瓜中的痕量分析方法,基于储藏稳定性研究阐明了其田间残留特征,并结合我国膳食结构评估了膳食暴露风险。样本经乙腈提取,衍生化后盐析离心,分散固相萃取(d-SPE)净化,超高效液相色谱质谱联用仪(UPLC-MS/MS)检测。缬菌胺、代森锰锌和ETU在葡萄和黄瓜基质中的平均回收率分别为84%~103%、86%~106%和83%~104%,相对标准偏差分别为1.1%~5.7%、0.8%~11.4%、4.4%~11.5%;-20℃避光条件下能在黄瓜和葡萄基质中分别稳定储藏720 d和758 d。缬菌胺和代森锰锌在黄瓜中的半衰期(1.7~2.4 d和1.4~2.7 d)均比在葡萄(6.5~30.1 d和8.6~12.8 d)中的短,而在葡萄中的最终残留浓度(<0.01~0.69 mg/kg)均比黄瓜(<0.01~0.16 mg/kg)中的高。两种果蔬中代森锰锌对儿童群体和一般人群急性膳食风险(%ARfD)分别为0.70%~3.68%和0.48%~2.53%,远低于100%;而代森锰锌和缬菌胺的联合慢性膳食风险为201.3%~831.7%,其中代森锰锌占比99.9%。可见,缬菌胺不会对我国消费者产生不可接受的膳食风险,但需警惕代森锰锌潜在高暴露风险,持续关注其在食物链中的生物累积风险,同步优化膳食结构,为其科学合理使用和健康风险规避提供理论依据。 |
| 英文摘要: |
| A trace analytical method for valifenalate, mancozeb and its metabolite ethylenethiourea (ETU) was established in grape and cucumber in this study. Based on the favorable storage stability, the fate characteristics of targeted compounds were clarified, and then highlighted their dietary exposure risks in combination with Chinese dietary structure. The samples were extracted with acetonitrile, then derivatized, salted out and centrifuged, and purified by dispersive solid-phase extraction (d-SPE), finally determined by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The mean recoveries of valifenalate, mancozeb and ETU in grape and cucumber matrices were 84%-103%, 86%-106% and 83%-104% with relative standard deviations (RSD) of 1.1%-5.7%, 0.8%-11.4% and 4.4%-11.5%. Target compounds could be stored stably for 720 d and 758 d at -20℃ in cucumbers and grapes under dark, respectively. The half-lives of valifenalate (1.7-2.4 d) and mancozeb (1.4-2.7 d) in cucumber were shorter than those in grape (6.5-30.1 d and 8.6-12.8 d). The residue levels of valifenalate and mancozeb in grape (<0.01－0.69 mg/kg) were higher than those in cucumber (<0.01－0.16 mg/kg). The acute dietary risks (%ARfD) of mancozeb in children and general population were 0.70% to 3.68% and 0.48% to 2.53%, respectively. The joint chronic dietary risks of mancozeb and valifenalate were 201.3% to 831.7%, of which mancozeb accounted for 99.9%. Therefore, valifenalate would not cause unacceptable exposure risk to consumers, however, the high potential exposure risk of mancozeb should be alerted and more attention should be paid to its bioaccumulation risk in the food chain. The dietary structure should also be optimized to provide a theoretical basis for the scientific application and risk avoidance of valifenalate and mancozeb. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
