| 杨凤环, 田 芳, 陈华民, 何晨阳*.病原细菌受体介导的c-di-GMP信号传导及其调控机制[J].植物保护,2017,43(1):9-14. |
| 病原细菌受体介导的c-di-GMP信号传导及其调控机制 |
| Cyclic di-GMP signal receptor-mediated regulation of bacterial behaviors |
| 投稿时间：2016-12-18 修订日期：2016-12-21 |
| DOI： |
| 中文关键词: c-di-GMP 信号代谢 受体 传导 调控 |
| 英文关键词:c-di-GMP signal metabolism receptor transduction regulation |
| 基金项目:国家自然科学基金项目(31671990, 31400117, 31370160, 31100947) |
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| 中文摘要: |
| 细菌第二信使环二鸟苷酸(c-di-GMP)信号网络系统主要涉及信号代谢、识别、接受、传递、功能表达和调控。c-di-GMP胞内水平受到鸟苷酸环化酶(DGC)和磷酸二酯酶(PDE)的控制。c-di-GMP信号受体类型多样, 包括转录调控因子、PilZ结构域蛋白、退化的GGDEF和EAL结构域蛋白、核糖体开关、多核苷酸磷酸化酶和新发现的蛋白激酶等。c-di-GMP受体接受信号后, 可以在转录、翻译以及翻译后水平上对下游靶标进行调控, 从而影响细菌的毒性、运动性、生物膜形成、细胞分裂等生理生化过程。本文结合本实验室对水稻白叶枯病菌的研究结果, 综述了近年来国内外在c-di-GMP信号受体介导的调控机制等方面的研究进展。 |
| 英文摘要: |
| The bacterial second message c-di-GMP signaling pathways mainly involve signal metabolism, signal recognition by receptor, reception and transduction, and phenotype expression and regulation. The intracellular level of c-di-GMP is precisely controlled by diguanylate cyclases (DGC) and phosphodiesterase (PDE) via biosynthesis or degradation, respectively. Several c-di-GMP receptors have been identified and characterized from various bacterial species, including transcription regulator, PilZ-domain protein, degenerate GGDEF or EAL domain protein, polynucleotide phosphorylase (PNPase), riboswitch and kinase, etc. The c-di-GMP receptors exert their regulatory functions at the transcription, translation, and post-translation levels, and regulate multiple bacterial properties including virulence, biofilm formation, motility and cell division. The recent progresses in c-di-GMP receptor-mediated regulation of bacterial behaviors were here reviewed, in combination with some of our findings on the bacterial blight pathogen of rice Xanthomonas oryzae pv. oryzae. |
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